Oxidative Stress by Ca2+ Overload is Critical for Phosphate-Induced Vascular Calcification
Abstract Hyperphosphatemia is the primary risk factor for vascular calcification, which is closely associated with cardiovascular morbidity and mortality. Recent evidence showed that oxidative stress by high inorganic phosphate (Pi) mediates calcific changes in vascular smooth muscle cells (VSMCs). However, intracellular signaling responsible for Pi-induced oxidative stress remains unclear. Here, we investigated molecular mechanisms of
Improving Existing Analysis Pipeline to Identify and Analyze Cancer Driver Genes Using Multi-omics Data
Abstract The cumulative of genes carrying mutations is vital for the establishment and development of cancer. However, this driver gene exploring research line has selected and used types of tools and models of analysis unsystematically and discretely. Also, the previous studies may have neglected low-frequency drivers and seldom predicted subgroup specificities of identified driver genes.
Accelerating Our Global Impact in the Year of the Nurse and Midwife
Abstract Confronting global health crises requires nurses who demonstrate leadership and the ability to collaborate with other disciplines. Regional partnerships can act as “accelerant synergists” to develop the capacity of nurses locally benefiting the region as a whole. Author: Upvall M.J Read more about the article here Read more about the author’s publications here